The field of proteomics is built on technologies to analyze large numbers of proteins—ideally
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …

Cortactin fulfills many functions in various cell types. These functions have been considered
to derive from its ability to activate the Actin-related protein 2/3 (Arp2/3) complex, and are …

Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling
pathways driving cell proliferation and survival have been difficult to identify, in part because …

Oxidative stress has been implicated in aging and many human diseases, notably
neurodegenerative disorders and various cancers. The reactive oxygen species that are …

The execution of complex biological processes requires the precise interaction and
regulation of thousands of molecules. Systematic approaches to study large numbers of …

Cellular processes such as proliferation, differentiation, and adaptation to environmental
changes are regulated by protein phosphorylation. Development of sensitive and …

Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

Protein phosphorylation is a key regulator of cellular signaling pathways. It is involved in
most cellular events in which the complex interplay between protein kinases and protein …

Phosphorylation by protein kinases is the most widespread and well-studied signaling
mechanism in eukaryotic cells. Phosphorylation can regulate almost every property of a …

Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by
dynamic phosphorylation events on a multitude of pathway proteins. Quantitative features …