Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes

E Skellam - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Cyclic natural product oligomers: diversity and (bio) synthesis of macrocycles

S Zhang, S Fan, H He, J Zhu, L Murray… - Chemical Society …, 2025 - pubs.rsc.org
Cyclic compounds are generally preferred over linear compounds for functional studies due
to their enhanced bioavailability, stability towards metabolic degradation, and selective …

Didepside Formation by the Nonreducing Polyketide Synthase Preu6 of Preussia isomera Requires Interaction of Starter Acyl Transferase and Thioesterase Domains

Q Liu, D Zhang, S Gao, X Cai, M Yao… - Angewandte Chemie …, 2023 - Wiley Online Library
Orsellinic acid (OA) derivatives are produced by filamentous fungi using nonreducing
polyketide synthases (nrPKSs). The chain‐releasing thioesterase (TE) domains of such …

Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme

L Kahlert, M Villanueva, RJ Cox… - Angewandte Chemie …, 2021 - Wiley Online Library
The polyketide synthase (PKS)‐like protein TerB, consisting of inactive dehydratase, inactive
C‐methyltransferase, and functional ketoreductase domains collaborates with the iterative …

[HTML][HTML] Synthetic microbes and biocatalyst designs in Thailand

D Trisrivirat, R Tinikul, P Chaiyen - Biotechnology Notes, 2023 - Elsevier
Furthering the development of the field of synthetic biology in Thailand is included in the
Thai government's Bio-Circular-Green (BCG) economic policy. The BCG model has …

Antifungal Activity of Menisporopsin A against Relevant Plant Pathogens

C Rodriguez, M Barrios-Jaén, LC Mejía, M Gutiérrez - Journal of Fungi, 2024 - mdpi.com
Current agrochemicals used in crop farming mainly consist of synthetic compounds with
harmful effects on the environment and human health. Crop-associated fungal endophytes …

Promoter tools for further development of Aspergillus oryzae as a platform for fungal secondary metabolite production

M Umemura, K Kuriiwa, LV Dao, T Okuda… - Fungal Biology and …, 2020 - Springer
Abstract Background The filamentous fungus Aspergillus oryzae is widely used for
secondary metabolite production by heterologous expression; thus, a wide variety of …

[HTML][HTML] De Novo Genome Assembly of Toniniopsis dissimilis (Ramalinaceae, Lecanoromycetes) from Long Reads Shows a Comparatively High Composition of …

JV Gerasimova, A Beck, A Scheunert, O Kulkarni - Genes, 2024 - mdpi.com
Lichens have developed numerous adaptations to optimize their survival in various
environmental conditions, largely by producing secondary compounds by the fungal partner …

Putative Biosynthesis of Talarodioxadione & Talarooxime from Talaromyces stipitatus

AJ Al Fahad - Molecules, 2022 - mdpi.com
Polyesters containing 2, 4-dihydroxy-6-(2-hydroxypropyl) benzoate and 3-hydroxybutyrate
moieties have been isolated from many fungal species. Talaromyces stipitatus was …

Recent advances in heterologous production of natural products using Aspergillus oryzae

J DONG, M LI, Z XIAO, M HU, Y MATSUDA… - Synthetic Biology …, 2022 - synbioj.cip.com.cn
Organic molecules produced by living organisms, generally termed as natural products, are
rich sources of pharmaceutical drugs and biopesticides, and fungi are one of the most …