Alzheimer's disease: risk factors and potentially protective measures
MVF Silva, CMG Loures, LCV Alves… - Journal of biomedical …, 2019 - Springer
Alzheimer's disease (AD) is the most common type of dementia and typically manifests
through a progressive loss of episodic memory and cognitive function, subsequently causing …
through a progressive loss of episodic memory and cognitive function, subsequently causing …
Vascular contributions to Alzheimer's disease
LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …
Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer's trial selection and disease monitoring
NJ Ashton, S Janelidze, N Mattsson-Carlgren… - Nature medicine, 2022 - nature.com
Blood biomarkers indicative of Alzheimer's disease (AD) pathology are altered in both
preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for …
preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for …
Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology
Importance Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer disease
(AD) pathology, with p-tau217 considered to have the most utility. However, availability of p …
(AD) pathology, with p-tau217 considered to have the most utility. However, availability of p …
Prediction of longitudinal cognitive decline in preclinical Alzheimer disease using plasma biomarkers
Importance Alzheimer disease (AD) pathology starts with a prolonged phase of β-amyloid
(Aβ) accumulation without symptoms. The duration of this phase differs greatly among …
(Aβ) accumulation without symptoms. The duration of this phase differs greatly among …
APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease
This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer's disease
(AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 …
(AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 …
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease
Abstract Background Trimethylamine N-oxide (TMAO), a small molecule produced by the
metaorganismal metabolism of dietary choline, has been implicated in human disease …
metaorganismal metabolism of dietary choline, has been implicated in human disease …
Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau
Importance The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein
E (APOE) gene, has a stronger association among women compared with men. Yet limited …
E (APOE) gene, has a stronger association among women compared with men. Yet limited …
The Brain Chart of Aging: machine‐learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING …
Introduction Relationships between brain atrophy patterns of typical aging and Alzheimer's
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
disease (AD), white matter disease, cognition, and AD neuropathology were investigated via …
An examination of a novel multipanel of CSF biomarkers in the Alzheimer's disease clinical and pathological continuum
C Van Hulle, EM Jonaitis, TJ Betthauser… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction This study examines the utility of a multipanel of cerebrospinal fluid (CSF)
biomarkers complementing Alzheimer's disease (AD) biomarkers in a clinical research …
biomarkers complementing Alzheimer's disease (AD) biomarkers in a clinical research …