Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study
conditions and diseases including those of the eye that lack appropriate animal models to …

Corneal dystrophies are broadly defined as inherited disorders that affect any layer of the
cornea and are usually progressive, bilateral conditions that do not have systemic effects …

Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …

Keratins are the forming units of intermediate filaments (IF) that provide mechanical support,
and formation of desmosomes between cells and hemi desmosomes with basement …

Autosomal dominantly inherited genetic disorders such as corneal dystrophies are
amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA …

Part of the lacrimal functional unit, the cornea protects the ocular surface from numerous
environmental aggressions and xenobiotics. Toxicological evaluation of compounds …

Corneal diseases are among the most prevalent causes of blindness worldwide. The
transparency and clarity of the cornea are guaranteed by a delicate physiological, anatomic …

Imbalance of potassium-ion levels in the body can lead to physiological dysfunctions, which
can adversely impact cardiovascular, neurological, and ocular health. Thus, quantitative …

During the last decades intermediate filaments (IFs) have emerged as important regulators
of cellular signaling events, ascribing IFs with functions beyond the structural support they …

Abstract Sulfur mustard (SM; bis (2-chloroethyl) sulfide) is a highly reactive bifunctional
alkylating agent synthesized for chemical warfare. The eyes are particularly sensitive to SM …