Secondary bacterial infections associated with influenza pandemics

DE Morris, DW Cleary, SC Clarke - Frontiers in microbiology, 2017 - frontiersin.org
Lower and upper respiratory infections are the fourth highest cause of global mortality.
Epidemic and pandemic outbreaks of respiratory infection are a major medical concern …

Platelet in thrombo-inflammation: Unraveling new therapeutic targets

S Sharma, T Tyagi, S Antoniak - Frontiers in immunology, 2022 - frontiersin.org
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae

V Sender, K Hentrich… - Frontiers in Cellular and …, 2021 - frontiersin.org
Secondary bacterial infections enhance the disease burden of influenza infections
substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the …

Microbiome disturbance and resilience dynamics of the upper respiratory tract during influenza A virus infection

D Kaul, R Rathnasinghe, M Ferres, GS Tan… - Nature …, 2020 - nature.com
Infection with influenza can be aggravated by bacterial co-infections, which often results in
disease exacerbation. The effects of influenza infection on the upper respiratory tract (URT) …

Respiratory Barrier as a Safeguard and Regulator of Defense Against Influenza A Virus and Streptococcus pneumoniae

KS LeMessurier, M Tiwary, NP Morin… - Frontiers in …, 2020 - frontiersin.org
The primary function of the respiratory system of gas exchange renders it vulnerable to
environmental pathogens that circulate in the air. Physical and cellular barriers of the …

Prostaglandin E2 as a regulator of immunity to pathogens

GJ Martínez-Colón, BB Moore - Pharmacology & therapeutics, 2018 - Elsevier
The body is exposed to foreign pathogens every day, but remarkably, most pathogens are
effectively cleared by the innate immune system without the need to invoke the adaptive …

Platelet-mediated NET release amplifies coagulopathy and drives lung pathology during severe influenza infection

SJ Kim, A Carestia, B McDonald, AZ Zucoloto… - Frontiers in …, 2021 - frontiersin.org
The influenza A virus (IAV) causes a respiratory tract infection with approximately 10% of the
population infected by the virus each year. Severe IAV infection is characterized by …

Inflammation as a modulator of host susceptibility to pulmonary influenza, pneumococcal, and co-infections

ER Aguilera, LL Lenz - Frontiers in immunology, 2020 - frontiersin.org
Bacterial and viral pathogens are predominant causes of pulmonary infections and
complications. Morbidity and mortality from these infections is increased in populations that …

Impfen bei Immundefizienz: Anwendungshinweise zu den von der Ständigen Impfkommission empfohlenen Impfungen.(III) Impfen bei hämatologischen und …

HJ Laws, U Baumann, C Bogdan, G Burchard… - 2020 - Springer
In Deutschland leben aktuell circa 4 Mio. Menschen, die in ihrem Leben eine
Krebserkrankung diagnostiziert bekommen haben [171]. Im Zeitraum von 1980–2017 …

Influenza A virus (H1N1) infection induces microglial activation and temporal dysbalance in glutamatergic synaptic transmission

HP Düsedau, J Steffen, CA Figueiredo, JD Boehme… - MBio, 2021 - Am Soc Microbiol
Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and
reoccurring epidemics affecting all age groups. Next to typical disease symptoms, such as …