Regulation of intestinal glucose absorption by ion channels and transporters

L Chen, B Tuo, H Dong - Nutrients, 2016 - mdpi.com
The absorption of glucose is electrogenic in the small intestinal epithelium. The major route
for the transport of dietary glucose from intestinal lumen into enterocytes is the Na+/glucose …

Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo‐controlled trial

B Zambrowicz, J Freiman, PM Brown… - Clinical …, 2012 - Wiley Online Library
Thirty‐six patients with type 2 diabetes mellitus (T2DM) were randomized 1: 1: 1 to receive a
once‐daily oral dose of placebo or 150 or 300 mg of the dual SGLT1/SGLT2 inhibitor …

Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets

JH He, LX Chen, H Li - Fitoterapia, 2019 - Elsevier
Diabetes mellitus (DM), a chronic metabolic disease, severely affects patients' life and
intensively increases risks of developing other diseases. It is estimated that 0.4 billion …

Improved glycemic control in mice lacking Sglt1 and Sglt2

DR Powell, CM DaCosta, J Gay… - American Journal …, 2013 - journals.physiology.org
Sodium-glucose cotransporter 2 (SGLT2) is the major, and SGLT1 the minor, transporter
responsible for renal glucose reabsorption. Increasing urinary glucose excretion (UGE) by …

Polymer–drug conjugates as nano-sized medicines

F Canal, J Sanchis, MJ Vicent - Current opinion in biotechnology, 2011 - Elsevier
Polymer Therapeutics have enormously evolved in the past decades. Several polymeric
drugs as well as polymer–protein conjugates have been in the market since the 90s, but …

1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

YG Li, DF Ji, S Zhong, TB Lin, ZQ Lv, GY Hu, X Wang - Scientific reports, 2013 - nature.com
We investigated the role of 1-deoxynojirimycin (DNJ) on glucose absorption and metabolism
in normal and diabetic mice. Oral and intravenous glucose tolerance tests and labeled 13C6 …

Traditional, indigenous apple varieties, a fruit with potential for beneficial effects: Their quality traits and bioactive polyphenol contents

L Jakobek, J Ištuk, I Buljeta, S Voća, JŠ Žlabur… - Foods, 2020 - mdpi.com
Earlier studies suggested that traditional apple varieties have quality traits well accepted by
consumers and beneficial effects on human health. The aim was to collect 25 traditional …

[图书][B] Encyclopedia of Polymer Applications, 3 Volume Set

M Mishra - 2018 - taylorfrancis.com
Undoubtedly the applications of polymers are rapidly evolving. Technology is continually
changing and quickly advancing as polymers are needed to solve a variety of day-to-day …

Oral drug delivery systems using chemical conjugates or physical complexes

TA Al-Hilal, F Alam, Y Byun - Advanced drug delivery reviews, 2013 - Elsevier
Oral delivery of therapeutics is extremely challenging. The digestive system is designed in a
way that naturally allows the degradation of proteins or peptides into small molecules prior …