Magnetic resonance imaging and spectroscopic techniques are widely used in humans both
for clinical diagnostic applications and in basic research areas such as cognitive …

Glycogen is a biologically essential macromolecule that is directly involved in multiple
human diseases. While its primary role in carbohydrate storage and energy metabolism in …

Proton MR spectra of the brain, especially those measured at short and intermediate echo
times, contain signals from mobile macromolecules (MM). A description of the main MM is …

Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3
disease) is a lysosomal storage disease characterized by progressive blindness, seizures …

Glycogen, a complex branched glucose polymer, is found in animals and bacteria, where it
serves as an energy storage molecule. It has linear (1→ 4)-α glycosidic bonds between …

Classic infantile Pompe disease is caused by abnormal lysosomal glycogen accumulation in
multiple tissues, including the brain due to a deficit in acid α-glucosidase. Although …

Glycogen stores in the brain have been recognized for decades, but the underlying
physiological function of this energy reserve remains elusive. This uncertainty stems in part …

It has been known for over 50 years that brain has significant glycogen stores, but the
physiological function of this energy reserve remains uncertain. This uncertainty stems in …

Brain glycogen build-up measured by magnetic resonance spectroscopy in classic infantile
Pompe disease Page 1 BRAIN COMMUNICATIONS https://doi.org/10.1093/braincomms/fcae303 …

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is an advanced magnetic
resonance imaging (MRI) technique that permits the molecular characterization by detecting …