European guidelines on the clinical management of HIV-1 tropism testing
LPR Vandekerckhove, AMJ Wensing… - The Lancet infectious …, 2011 - thelancet.com
Viral tropism is the ability of viruses to enter and infect specific host cells and is based on the
ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended …
ability of viruses to bind to receptors on those cells. Testing for HIV tropism is recommended …
[PDF][PDF] Genotypic determination of HIV tropism-clinical and methodological recommendations to guide the therapeutic use of CCR5 antagonists
The approval of maraviroc (Selzentri®), the first CCR5 antagonist, with specific antiviral
activity against CCR5 (R5)-tropic HIV variants, has promoted the determination of HIV …
activity against CCR5 (R5)-tropic HIV variants, has promoted the determination of HIV …
Evaluation of the genotypic prediction of HIV-1 coreceptor use versus a phenotypic assay and correlation with the virological response to maraviroc: the ANRS …
P Recordon-Pinson, C Soulié, P Flandre… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Genotypic algorithms for prediction of HIV-1 coreceptor usage need to be evaluated in a
clinical setting. We aimed at studying (i) the correlation of genotypic prediction of coreceptor …
clinical setting. We aimed at studying (i) the correlation of genotypic prediction of coreceptor …
Assessing advances in three decades of clinical antiretroviral therapy on the HIV-1 reservoir
I González-Navarro, V Urrea, C Gálvez… - The Journal of Clinical …, 2024 - jci.org
BACKGROUND. Antiretroviral therapy (ART) has improved the clinical management of HIV-
1 infection. However, little is known about how the latest ART recommendations affect the …
1 infection. However, little is known about how the latest ART recommendations affect the …
[HTML][HTML] Extremely low viral reservoir in treated chronically HIV-1-infected individuals
Background Small viral reservoirs are found predominantly in HIV-1 controllers and
individuals treated during acute/early HIV-1 infection. However, other HIV+ individuals could …
individuals treated during acute/early HIV-1 infection. However, other HIV+ individuals could …
A genotypic test for HIV-1 tropism combining Sanger sequencing with ultradeep sequencing predicts virologic response in treatment-experienced patients
RM Kagan, EP Johnson, M Siaw, P Biswas… - 2012 - journals.plos.org
A tropism test is required prior to initiation of CCR5 antagonist therapy in HIV-1 infected
individuals, as these agents are not effective in patients harboring CXCR4 (X4) coreceptor …
individuals, as these agents are not effective in patients harboring CXCR4 (X4) coreceptor …
Reliable genotypic tropism tests for the major HIV-1 subtypes
K Cashin, LR Gray, KL Harvey, D Perez-Bercoff… - Scientific reports, 2015 - nature.com
Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-
1 infected individuals, yet achieving better access to vulnerable populations remains a …
1 infected individuals, yet achieving better access to vulnerable populations remains a …
Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks
Background Drug resistance in HIV treatment is still a worldwide problem. Predicting
resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction …
resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction …
[PDF][PDF] Update on clinical and methodological recommendations for genotypic determination of HIV tropism to guide the usage of CCR5 antagonists
The genotypic determination of HIV tropism to guide the use of maraviroc, the first CCR5
antagonist with specific antiviral activity against CCR5 (R5)-tropic HIV variants, has been …
antagonist with specific antiviral activity against CCR5 (R5)-tropic HIV variants, has been …
Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping
MCF Prosperi, L Bracciale, M Fabbiani… - Retrovirology, 2010 - Springer
Background Trofile® is the prospectively validated HIV-1 tropism assay. Its use is limited by
high costs, long turn-around time, and inability to test patients with very low or undetectable …
high costs, long turn-around time, and inability to test patients with very low or undetectable …