We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Brain network hubs are both highly connected and highly inter-connected, forming a critical
communication backbone for coherent neural dynamics. The mechanisms driving this …

Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder that results from the interaction of both genetic and environmental risk factors …

Introduction Substantial links between autoimmune diseases have been shown by an
increasing number of studies, and one hypothesis for this comorbidity is that there is a …

Gene-based association tests aggregate multiple SNP-trait associations into sets defined by
gene boundaries and are widely used in post-GWAS analysis. A common approach for gene …

The complex aetiology of schizophrenia is postulated to share components with other
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …

Family and population studies indicate clear heritability of major depressive disorder (MDD),
though its underlying biology remains unclear. The majority of single-nucleotide …

The accumulation of vast amounts of multimodal data for the human brain, in both normal
and disease conditions, has provided unprecedented opportunities for understanding why …

Alzheimer's disease is the most common form of dementia. Notwithstanding the huge
investments in drug development, only one disease-modifying treatment has been recently …