Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Genetic information is stored in linear DNA molecules, which are highly folded inside cells.
DNA replication along the folded template path yields two sister chromatids that initially …

After 60 years of chromatin investigation, our understanding of chromatin organization has
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …

Centromeric chromatin is thought to play a critical role in ensuring the faithful segregation of
chromosomes during mitosis. However, our understanding of this role is presently limited by …

The conformational dynamics of nucleosome arrays generate a diverse spectrum of
microscopic states, posing challenges to their structural determination. Leveraging …

The dynamics of DNA in the cell nucleus plays a role in cellular processes and fates but the
interplay of DNA mobility with the hierarchical levels of DNA organization is still …

The human genome is tightly packed into the 3D environment of the cell nucleus. Rapidly
evolving and sophisticated methods of mapping 3D genome architecture have shed light on …

Inside the nucleus, chromosomes are subjected to direct physical interaction between
different components, active forces, and thermal noise, leading to the formation of an …

Most animal genomes are partitioned into Topologically Associating Domains (TADs),
created by cohesin-mediated loop extrusion and defined by convergently oriented CTCF …