In spite of significant progress towards malaria control and elimination achieved in South
America in the 2000s, this mosquito-transmitted tropical disease remains an important public …

Primaquine is the only available antimalarial drug that kills dormant liver stages of
Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse …

Abstract Background Treatment of Plasmodium vivax malaria requires the clearing of
asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared …

Background Primaquine is the only widely used drug that prevents Plasmodium vivax
malaria relapses, but adherence to the standard 14-day regimen is poor. We aimed to …

Background High levels of patient adherence to antimalarial treatment are important in
ensuring drug effectiveness. To achieve this goal, it is important to understand levels of …

Background Despite recent intensification of control measures, Plasmodium vivax poses a
major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause …

Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it
has been proposed that a proportion of these cases are due to primaquine (PQ) treatment …

Background Recent efforts in malaria control have resulted in great gains in reducing the
burden of Plasmodium falciparum, but P. vivax has been more refractory. Its ability to form …

Background Malaria control activities can have a disproportionately greater impact on
Plasmodium falciparum than on P. vivax in areas where both species are coendemic. We …

Brazil is the largest country of Latin America, with a considerable portion of its territoritory
within the malaria-endemic Amazon region in the North. Furthermore, a considerable portion …