Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins
encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA) …

Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …

Cancer metabolism is rewired to support cell survival in response to intrinsic and
environmental stressors. Identification of strategies to target these adaptions is an area of …

Autophagy is an essential catabolic process that promotes the clearance of surplus or
damaged intracellular components. Loss of autophagy in age-related human pathologies …

Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Although deregulation of transfer RNA (tRNA) biogenesis promotes the translation of pro-
tumorigenic mRNAs in cancers,, the mechanisms and consequences of tRNA deregulation …