Thyroid peroxidase as a dual active site enzyme: Focus on biosynthesis, hormonogenesis and thyroid disorders of autoimmunity and cancer
M Godlewska, PJ Banga - Biochimie, 2019 - Elsevier
Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis.
Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD) …
Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD) …
Structural basis of activation of mammalian heme peroxidases
The mammalian heme peroxidases including lactoperoxidase (LPO), myeloperoxidase
(MPO), eosinophil peroxidase (EPO) and thyroid peroxidase (TPO) contain a covalently …
(MPO), eosinophil peroxidase (EPO) and thyroid peroxidase (TPO) contain a covalently …
Dual binding mode of “bitter sugars” to their human bitter taste receptor target
F Fierro, A Giorgetti, P Carloni, W Meyerhof… - Scientific reports, 2019 - nature.com
The 25 human bitter taste receptors (hTAS2Rs) are responsible for detecting bitter
molecules present in food, and they also play several physiological and pathological roles in …
molecules present in food, and they also play several physiological and pathological roles in …
Design, synthesis, molecular modeling, and biological evaluation of novel thiouracil derivatives as potential antithyroid agents
Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of
the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X …
the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X …
In-silico studies of Brassica oleracea active compounds and their role in thyroid peroxidase activity
Cabbage, a leafy vegetable that is widely consumed across the globe, holds a significant
place within the Brassica family. For almost a century, its potential anti-thyroid effects have …
place within the Brassica family. For almost a century, its potential anti-thyroid effects have …
Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98 Å resolution
Lactoperoxidase (LPO) is a member of mammalian heme peroxidase superfamily whose
other members are myeloperoxidase (MPO), eosinophil peroxidase (EPO) and thyroid …
other members are myeloperoxidase (MPO), eosinophil peroxidase (EPO) and thyroid …
[HTML][HTML] Biologically-guided isolation of natural lead antithyroid drug from Medicago sativa L. sprouts and its toxic profile in comparison with propylthiouracil
Hyperthyroidism is a common endocrine disorder associated with increased risk of
cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved …
cardiovascular complications and mortality. Although antithyroid drugs (ATDs) are approved …
Exploring mammalian heme peroxidases: A comprehensive review on the structure and function of myeloperoxidase, lactoperoxidase, eosinophil peroxidase, thyroid …
The peroxidase family of enzymes is a ubiquitous cluster of enzymes primarily responsible
for the oxidation of organic and inorganic substrates. The mammalian heme peroxidase …
for the oxidation of organic and inorganic substrates. The mammalian heme peroxidase …
Biochemical and Structural Characterisation of a Bacterial Lactoperoxidase
Peroxidases belong to a group of enzymes that are widely found in animals, plants and
microorganisms. These enzymes are effective biocatalysts for a wide range of oxidations on …
microorganisms. These enzymes are effective biocatalysts for a wide range of oxidations on …
Role of halogen and hydrogen bonds for stabilization of antithyroid drugs with hypohalous acids (HOX, X= I, Br, and Cl) adducts
HS El-Sheshtawy, I El-Mehasseb - Journal of Molecular Structure, 2017 - Elsevier
The mechanism for the inhibition of thyroid hormones by the thioamide-like antithyroid drug
is a key process in the thyroid gland function. Therefore, in this study theoretical …
is a key process in the thyroid gland function. Therefore, in this study theoretical …