Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Antagonists of the transient receptor potential vanilloid-1 (TRPV1) channel alter body
temperature (T b) in laboratory animals and humans: most cause hyperthermia; some …

Single particle cryo-EM often yields multiple protein conformations within a single dataset,
but experimentally deducing the temporal relationship of these conformers within a …

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

Abstract Background Both Chili pepper (CP) and Sichuan pepper (SP) have long been used
for culinary purposes throughout Asia. It is well known CP and SP are well accompanied in …

The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …

The regulation of the cell membrane potential plays a crucial role in governing the
transmembrane transport of various ions and cellular life processes. However, in situ and on …

Menthol in mints elicits coolness sensation by selective activation of TRPM8 ion channel.
Although structures of TRPM8 channel were determined by cryo-EM in the apo and liganded …

The human voltage-gated sodium channel, hNaV1. 5, is responsible for the rapid upstroke of
the cardiac action potential and is target for antiarrhythmic therapy. Despite the clinical …