The neuroprotective potentiality of flavonoids on Alzheimer's disease
Alzheimer's disease (AD), due to its spread, has become a global health priority, and is
characterized by senile dementia and progressive disability. The main cause of AD and …
characterized by senile dementia and progressive disability. The main cause of AD and …
Molecular dynamics-driven drug discovery: leaping forward with confidence
Highlights•Currently, developing a market-approved drug costs a staggering $2.6 billion.•In
silico methods have become an important strategy for narrowing down on promising lead …
silico methods have become an important strategy for narrowing down on promising lead …
Molecular insight into the binding property and mechanism of sulfamethoxazole to extracellular proteins of anammox sludge
GF Li, WJ Ma, ZQ Ren, Y Wang, JP Li… - Environmental …, 2021 - ACS Publications
Antibiotics are widely found in nitrogen-containing wastewater, which may affect the
operation stability of anaerobic ammonium oxidation (anammox)-based biological treatment …
operation stability of anaerobic ammonium oxidation (anammox)-based biological treatment …
An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
Explore the effect of the structure-activity relationship and dose-effect relationship on the antioxidant activity of licorice flavonoids
Y Hu, P Liang, Z Wang, CP Jiang, Q Zeng… - Journal of Molecular …, 2023 - Elsevier
Licorice flavonoids (LCF) are one of the homologous substances of medicine and food,
which have good antioxidant activity. However, the molecular mechanism affecting its …
which have good antioxidant activity. However, the molecular mechanism affecting its …
Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery
KV Dileep, K Ihara, C Mishima-Tsumagari… - International Journal of …, 2022 - Elsevier
Alzheimer's disease (AD) is one of the most common, progressive neurodegenerative
disorders affecting the aged populations. Though various disease pathologies have been …
disorders affecting the aged populations. Though various disease pathologies have been …
Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2
Abstract Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A,
belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral …
belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral …
Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational …
AS Abdul Manap, AC Wei Tan, WH Leong… - Frontiers in aging …, 2019 - frontiersin.org
Hallmarks of Alzheimer's disease (AD) pathology include acetylcholine (ACh) deficiency and
plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact …
plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact …
Design, synthesis, and pharmacological evaluation of embelin–aryl/alkyl amine hybrids as orally bioavailable blood–brain barrier permeable multitargeted agents with …
VK Nuthakki, S Choudhary, CN Reddy… - ACS chemical …, 2023 - ACS Publications
The complex and multifaceted nature of Alzheimer's disease has brought about a pressing
demand to develop ligands targeting multiple pathways to combat its outrageous …
demand to develop ligands targeting multiple pathways to combat its outrageous …
Phenoxyethyl piperidine/morpholine derivatives as PAS and CAS inhibitors of cholinesterases: insights for future drug design
Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …