Ischemia–reperfusion–induced lung injury is characterized by nonspecific alveolar damage,
lung edema, and hypoxemia occurring within 72 hours after lung transplantation. The most …

Lung ischemia-reperfusion injury remains one of the major complications after cardiac
bypass surgery and lung transplantation. Due to its dual blood supply system and the …

Background More than 80% of donor lungs are potentially injured and therefore not
considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion …

Cold static preservation on ice (~ 4° C) remains the clinical standard of donor organ
preservation. However, mitochondrial injury develops during prolonged storage, which limits …

BACKGROUND: The inhibition of cellular metabolism induced by hypothermia obviates the
possibility of substantial reparative processes occurring during organ preservation. The aim …

OBJECTIVE: Normothermic ex vivo lung perfusion is a novel method to evaluate and
improve the function of injured donor lungs. We reviewed our experience with 50 …

Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …

Treatment of injured donor lungs ex vivo to accelerate organ recovery and ameliorate
reperfusion injury could have a major impact in lung transplantation. We have recently …

We previously described a technique for en bloc double-lung transplantation that was
initially applied to select patients with cystic fibrosis and emphysema. This procedure is quite …

The lack of suitable donors for all solid-organ transplant programs is exacerbated in lung
transplantation by the low utilization of potential donor lungs, due primarily to donor lung …