Over the last several years, the increasing prevalence of obesity has favored an intense study of adipose tissue biology and the precise mechanisms involved in adipocyte …
AJ Richard, U White, CM Elks, JM Stephens - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is expanding. Just in the past decade, substantial advances have led to new insights into the …
E Gomez-Sanchez… - Comprehensive …, 2014 - ncbi.nlm.nih.gov
The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and …
G Lastra, S Syed, LR Kurukulasuriya… - Endocrinology and …, 2014 - endo.theclinics.com
Hypertension (HTN) is present in more than 50% of patients with diabetes mellitus (DM) and contributes significantly to both microvascular and macrovascular disease in DM (Fig. 1). 1 …
MJ Lee, P Pramyothin, K Karastergiou… - Biochimica et Biophysica …, 2014 - Elsevier
Central obesity is associated with insulin resistance and dyslipidemia. Thus, the mechanisms that control fat distribution and its impact on systemic metabolism have …
The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors, including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …
F Jaisser, N Farman - Pharmacological reviews, 2016 - ASPET
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …
New therapeutic and preventative strategies are needed to address the growing obesity epidemic. In animal models, brown adipose tissue activation and the associated heat …
PM de Sá, AJ Richard, H Hang… - Comprehensive …, 2011 - Wiley Online Library
Adipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that …