Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Mastitis is considered the costliest disease on dairy farms and also adversely affects animal
welfare. As treatment (and to a lesser extent prevention) of mastitis rely heavily on …

Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a global health threat,
especially with the continuous development of antibiotic resistance. As an opportunistic …

Highlights•Endolysins are promising novel therapeutics for treatment of bacterial
infections.•Endolysins can target infections in different organs and tissues of the human …

One of the possible solutions for the current antibiotic resistance crisis may be found in
(often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these …

Presently, biopreservation through protective bacterial cultures and their antimicrobial
products or using antibacterial compounds derived from plants are proposed as feasible …