Ion channels and channelopathies in glomeruli
A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
Nephrin signaling in the podocyte: an updated view of signal regulation at the slit diaphragm and beyond
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …
the morphology of their unique actin-based foot processes (FP) are a common feature of …
A BK (Slo1) channel journey from molecule to physiology
Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology,
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …
TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology
Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
genetic forms of glomerular disease are caused by mutations in genes that encode structural …
Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species
Insulin receptors in podocytes are essential for normal kidney function. Here, we show that
insulin evokes a rapid increase in the surface expression of canonical transient receptor …
insulin evokes a rapid increase in the surface expression of canonical transient receptor …
Balancing calcium signals through TRPC5 and TRPC6 in podocytes
A Greka, P Mundel - Journal of the American Society of …, 2011 - journals.lww.com
Abstract Calcium (Ca 2+) ions are important mediators of cellular homeostasis owing to their
ability to elicit a dynamic, transient, and tightly regulated range of biochemical responses …
ability to elicit a dynamic, transient, and tightly regulated range of biochemical responses …
[HTML][HTML] TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease
Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …
Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol
M Anderson, EY Kim, H Hagmann… - … of Physiology-Cell …, 2013 - journals.physiology.org
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily
C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding podocin result in …
C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding podocin result in …
Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis
Y Xia, LC Herlitz, S Gindea, J Wen… - Journal of the …, 2015 - journals.lww.com
TNF ligand superfamily member 12, also known as TNF-related weak inducer of apoptosis
(TWEAK), acts through its receptor, fibroblast growth factor-inducible 14 (Fn14), to mediate …
(TWEAK), acts through its receptor, fibroblast growth factor-inducible 14 (Fn14), to mediate …
MaxiK channel and cell signalling
L Toro, M Li, Z Zhang, H Singh, Y Wu… - Pflügers Archiv-European …, 2014 - Springer
Abstract The large-conductance Ca 2+-and voltage-activated K+(MaxiK, BK, BK Ca, Slo1, K
Ca 1.1) channel role in cell signalling is becoming apparent as we learn how the channel …
Ca 1.1) channel role in cell signalling is becoming apparent as we learn how the channel …