Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to
the formation of a glial scar. In this environment, axon regeneration fails, and remyelination …

This article reviews the pathology of human spinal cord injury (SCI), focusing on potential
differences between humans and experimental animals, as well as on aspects that may …

Traumatic damage to the central nervous system (CNS) destroys the blood–brain barrier
(BBB) and provokes the invasion of hematogenous cells into the neural tissue. Invading …

It is widely accepted that the adult mammalian central nervous system (CNS) is unable to
regenerate axons. In addition to physical or molecular barriers presented by glial scarring at …

Local spinal cord lesions are often greatly enlarged by secondary damage, a process which
leads to massive additional cell death. This process is poorly understood. In order to …

We have recently reported that minimally disturbed adult CNS white matter can support
regeneration of adult axons by using a novel microtransplantation technique to inject minute …

The influence of tethering silicon microelectrode arrays on the cortical brain tissue reaction
was compared with that of untethered implants placed in the same location by identical …

The present study provides the first evidence that signaling occurs between B-ephrins and
EphB receptors in the adult CNS in response to injury. Specifically, our combined …

Transforming growth factor-beta 1 (TGF-beta 1) has been shown to up-regulate the
synthesis of nerve growth factor (NGF) in cultured rat astrocytes and in neonatal brain in vivo …

Reactive astrogliosis is a characteristic response of astrocytes to inflammation and trauma of
the adult CNS. To assess the hypothesis that cytokines from inflammatory mononuclear cells …