Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain

AP Simopoulos - Molecular neurobiology, 2011 - Springer
Several sources of information suggest that human beings evolved on a diet that had a ratio
of omega-6 to omega-3 fatty acids (FA) of about 1/1; whereas today, Western diets have a …

The membrane hypothesis of schizophrenia

DF Horrobin, AIM Glen, K Vaddadi - Schizophrenia research, 1994 - Elsevier
The phospholipid structure of neuronal membranes is essential for normal functioning of the
nervous system. Evidence is accumulating that phospholipid metabolism in both brain and …

Cognitive and physiological effects of Omega‐3 polyunsaturated fatty acid supplementation in healthy subjects

G Fontani, F Corradeschi, A Felici… - European journal of …, 2005 - Wiley Online Library
Background It has been reported that Omega‐3 fatty acids may play a role in nervous
system activity and that they improve cognitive development and reference memory‐related …

Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia

M Peet, J Brind, CN Ramchand, S Shah… - Schizophrenia research, 2001 - Elsevier
Evidence that the metabolism of phospholipids and polyunsaturated fatty acids (PUFA) is
abnormal in schizophrenia provided the rationale for intervention studies using PUFA …

Free radical pathology and antioxidant defense in schizophrenia: a review

SP Mahadik, S Mukherjee - Schizophrenia research, 1996 - Elsevier
There is increasing evidence that free radical-mediated CNS neuronal dysfunction is
involved in the pathophysiology of schizophrenia. Free radicals (oxyradicals, such as …

Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia

WS Fenton, J Hibbeln, M Knable - Biological psychiatry, 2000 - Elsevier
Recent research suggests that deficient uptake or excessive breakdown of membrane
phospholipids may be associated with schizophrenia. We review available clinical research …

Plasma fatty acid levels in autistic children

S Vancassel, G Durand, C Barthelemy… - … and Essential Fatty …, 2001 - Elsevier
Phospholipid fatty acids are major structural components of neuronal cell membranes, which
modulate membrane fluidity and hence function. Evidence from clinical and biochemical …

A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms

M Peet, DF Horrobin… - Journal of psychiatric …, 2002 - Elsevier
The objective was to test effects of ethyl eicosapentaenoate (EE) on persistent ongoing
symptoms in patients receiving different types of anti-schizophrenic drugs, typical …

Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years …

MM Khan, DR Evans, V Gunna, RE Scheffer… - Schizophrenia …, 2002 - Elsevier
Abnormal membrane phospholipid essential polyunsaturated fatty acid (EPUFA) metabolism
(ie, reduced incorporation into phospholipids and increased breakdown) has been …

Herbal remedies in psychiatric practice

AHC Wong, M Smith, HS Boon - Archives of general psychiatry, 1998 - jamanetwork.com
Patients' use of alternative and complementary health services has created a need for
physicians to become informed about the current literature regarding these treatments …