For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived
antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell …

Simple Summary Prostate cancer treatment has improved over the last 20 years; despite
this, approximately 33,000 men died from the disease in the United States in 2020. In view of …

The balance between excitation and inhibition controls fundamental aspects of the
hippocampal function. Here, we report an increase in the ratio of inhibitory to excitatory …

Executioner caspase-3 and-7 are proteases promoting cell death but non-apoptotic roles
are being discovered. The heart expresses caspases only during development, suggesting …

Naturally occurring cell death is essential to the development of the mammalian nervous
system. Although the importance of developmental cell death has been appreciated for …