As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …