Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

Synapses exhibit several forms of short-term plasticity that play a multitude of computational
roles. Short-term depression suppresses neurotransmitter release for hundreds of …

Calmodulin (CaM) is a ubiquitous, highly conserved, eukaryotic protein that binds to and
regulates a number of diverse target proteins involved in different functions such as …

The unc-13 homolog B (UNC13B) gene encodes a presynaptic protein, mammalian
uncoordinated 13-2 (Munc13-2), which is highly expressed in the brain—predominantly in …

Alzheimer's disease (AD) is a common form of dementia in aged people, which is defined by
two pathological characteristics: β-amyloid protein (Aβ) deposition and tau …

Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-
priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how …

Short-term synaptic plasticity, the dynamic alteration of synaptic strength during high-
frequency activity, is a fundamental characteristic of all synapses. At the calyx of Held …

Calmodulin is a prototypical and versatile Ca 2+ sensor with EF hands as its high-affinity Ca
2+ binding domains. Calmodulin is present in all eukaryotic cells, mediating Ca 2+ …

Calmodulin (CaM) is a universal regulator for a huge number of proteins in all eukaryotic
cells. Best known is its function as a calcium-dependent modulator of the activity of enzymes …