Regulation and role of CAMKK2 in prostate cancer
TL Pulliam, P Goli, D Awad, C Lin… - Nature Reviews …, 2022 - nature.com
Abstract In 2011, CAMKK2, the gene encoding calcium/calmodulin-dependent kinase
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
kinase 2 (CAMKK2), was demonstrated to be a direct target of the androgen receptor and a …
Applications of isothermal titration calorimetry in pure and applied research from 2016 to 2020
RJ Falconer, B Schuur… - Journal of Molecular …, 2021 - Wiley Online Library
The last 5 years have seen a series of advances in the application of isothermal titration
microcalorimetry (ITC) and interpretation of ITC data. ITC has played an invaluable role in …
microcalorimetry (ITC) and interpretation of ITC data. ITC has played an invaluable role in …
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
C Lin, AM Blessing, TL Pulliam, Y Shi, SR Wilkenfeld… - Oncogene, 2021 - nature.com
Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer
progression in part through the modulation of autophagy. However, clinical trials testing …
progression in part through the modulation of autophagy. However, clinical trials testing …
Hinge binder scaffold hopping identifies potent calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) inhibitor chemotypes
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is
linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to …
linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to …
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing
LM McAloon, AG Muller, K Nay, EL Lu… - Essays in …, 2024 - portlandpress.com
Abstract Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that
regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different …
regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different …
The role of small molecule Flt3 receptor protein-tyrosine kinase inhibitors in the treatment of Flt3-positive acute myelogenous leukemias
R Roskoski Jr - Pharmacological Research, 2020 - Elsevier
Flt3 is expressed by early myeloid and lymphoid progenitor cells and it regulates the
proliferation and differentiation of hematopoietic cells. Flt3 is activated by the Flt3 ligand, the …
proliferation and differentiation of hematopoietic cells. Flt3 is activated by the Flt3 ligand, the …
In depth analysis of kinase cross screening data to identify CAMKK2 inhibitory scaffolds
SN O'Byrne, JW Scott, JR Pilotte, AS Santiago… - Molecules, 2020 - mdpi.com
The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1,
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of …
Stabilization of protein–protein interactions between CaMKK2 and 14–3–3 by Fusicoccins
D Lentini Santo, O Petrvalska, V Obsilova… - ACS chemical …, 2020 - ACS Publications
Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates several key
physiological and pathophysiological processes, and its dysregulation has been implicated …
physiological and pathophysiological processes, and its dysregulation has been implicated …
CaMKK2 knockout bone marrow cells collected/processed in low oxygen (Physioxia) suggests CaMKK2 as a hematopoietic stem to progenitor differentiation fate …
HE Broxmeyer, J Ropa, ML Capitano, S Cooper… - Stem cell reviews and …, 2022 - Springer
Little is known about a regulatory role of CaMKK2 for hematopoietic stem (HSC) and
progenitor (HPC) cell function. To assess this, we used Camkk2−/− and wild type (WT) …
progenitor (HPC) cell function. To assess this, we used Camkk2−/− and wild type (WT) …
Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions …
Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to
prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo …
prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo …