A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration

LD Orozco, LA Owen, J Hofmann, AD Stockwell, J Tao… - Cell genomics, 2023 - cell.com
Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Genome wide association study and genomic risk prediction of age related macular degeneration in Israel

M Grunin, D Triffon, G Beykin, E Rahmani… - Scientific Reports, 2024 - nature.com
The risk of developing age-related macular degeneration (AMD) is influenced by genetic
background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 …

[HTML][HTML] Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and …

A Stepanyan, A Brojakowska… - Cardiovascular …, 2024 - pmc.ncbi.nlm.nih.gov
Background Long-term consumption of Western Diet (WD) is a well-established risk factor
for the development of cardiovascular disease (CVD); however, there is a paucity of studies …

Long-term outcome of neovascular age-related macular degeneration: association between treatment outcome and major risk alleles

BN Vofo, G Beykin, J Levy, I Chowers - British Journal of …, 2022 - bjo.bmj.com
Aims To evaluate the long-term functional and anatomical outcomes of neovascular age-
related macular degeneration (nvAMD) treated with intravitreal anti-vascular endothelial …

CFH (rs1061170, rs1410996), KDR (rs2071559, rs1870377) and KDR and CFH Serum Levels in AMD Development and Treatment Efficacy

D Cebatoriene, A Vilkeviciute, G Gedvilaite, A Bruzaite… - Biomedicines, 2024 - mdpi.com
Background: Age-related macular degeneration (AMD) is a major global health problem as it
is the leading cause of irreversible loss of central vision in the aging population. Av-vascular …

Identifying X-chromosome variants associated with age-related macular degeneration

M Grunin, RP Igo Jr, YE Song… - Human molecular …, 2024 - academic.oup.com
Purpose: In genome-wide association studies (GWAS), X chromosome (ChrX) variants are
often not investigated. Sex-specific effects and ChrX-specific quality control (QC) are needed …

Genetic association analysis of anti-VEGF treatment response in neovascular age-related macular degeneration

T Strunz, M Pöllmann, MA Gamulescu, S Tamm… - International Journal of …, 2022 - mdpi.com
Anti-VEGF treatment for neovascular age-related macular degeneration (nAMD) has been
FDA-approved in 2004, and since then has helped tens of thousands of patients worldwide …

[PDF][PDF] Фармакогенетические особенности эффективности применения антиангиогенной терапии при неоваскулярной возрастной макулярной дегенерации

БА Касыгулова, НА Гаврилова, ВВ Кадышев… - … . 2023. Том 19. № 11 … - umedp.ru
Возрастная макулярная дегенерация (ВМД)–прогрессирующее заболевание,
характеризующееся поражением макулярной зоны (центральной зоны сетчатки в …

Targeted therapy in age-related macular degeneration (AMD)

KD Szumna, F Piędel, AA Rocka, DK Madras… - Journal of Education …, 2020 - apcz.umk.pl
Conclusions: Looking at the number of blindness cases in highly developed countries
caused by AMD, every effort should be made to introduce effective treatment that at least …

[引用][C] The influence of genetic and environmental factors on inter-individual and inter-population variations

F Cheng - 2024 - espace.library.uq.edu.au
Humans exhibit a diverse range of variations in complex traits including behaviors and
diseases. The trait variations within and between populations, also known as inter-individual …