For centuries, philosophers and scientists have been fascinated by the principles and
implications of regeneration in lower vertebrate species. Two features have made zebrafish …

Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this
regenerative response are Müller glia that respond to retinal injury by undergoing a …

Neuronal progenitors in the mammalian brain derive from radial glia or specialized
astrocytes. In developing neural retina, radial glia-like Müller cells are generated late in …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Background The persistence in adult teleost fish of retinal stem cells that exhibit all of the
features of true'adult stem cells'–self-renewal, multipotency, and the capacity to respond to …

Key to successful retina regeneration in zebrafish are Müller glia (MG) that respond to retinal
injury by dedifferentiating into a cycling population of retinal progenitors. Although recent …

We examined the regenerative capacity of the adult zebrafish retina by intravitreal injection
of a low ouabain concentration to rapidly damage the ganglion cell layer (GCL) and inner …

purpose. To use progenitor cells isolated from the neural retina for transplantation studies in
mice with retinal degeneration. methods. Retinal progenitor cells from postnatal day 1 green …

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …