Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …

Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many
cellular functions, such as cell proliferation, apoptosis, the cell cycle and DNA repair. It is …

The clustered homeobox proteins play crucial roles in development, hematopoiesis, and
leukemia, yet the targets they regulate and their mechanisms of action are poorly …

The paediatric eye tumour retinoblastoma is initiated by inactivation of RB1, a tumour
suppressor on chromosome 13q. In addition to RB1 loss, many retinoblastomas show other …

The human DEK gene is frequently overexpressed and sometimes amplified in human
cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to …

NUP214 is a component of the nuclear pore complex (NPC) with a key role in protein and
mRNA nuclear export. Chromosomal translocations involving the NUP214 locus are …

Early studies of the inhibitor of growth 1 (ING1) gene, the founding member of the ING tumor
suppressor family, demonstrated that this gene plays an important role in apoptosis and …

High levels of expression of the human DEK gene have been correlated with numerous
human malignancies. Intracellular DEK functions have been described in vitro and include …

Slight modifications of chromatin dynamics can translate into small-and large-scale changes
in DNA replication and DNA repair. Similarly, promoter usage and accessibility are tightly …

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis
presenting with peripheral cytopenias in combination with a hyperplastic bone marrow and …