Cancer incidences are growing and cause millions of deaths worldwide. Cancer therapy is
one of the most important challenges in medicine. Improving therapeutic outcomes from …

Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer
cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence …

BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse
range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins …

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis,
necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (eg …

Glioblastoma (GBM) is uniformly fatal with a median survival of just over 1 year, despite best
available treatment including radiotherapy (RT). Impacts of prior brain RT on recurrent …

Background Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are
cross-resistant to irradiation. Here, we investigated the mechanisms associated with …

Cancer originates from genetic mutations accumulation. Cancer stem cells have been
depicted as tumorigenic cells that can differentiate and self‐renew. Cancer stem cells are …

The mammalian target of rapamycin (mTOR) is the major controller of a number of important
cellular activities, including protein synthesis, cell expansion, multiplication, autophagy …

The DNA single-strand break (SSB) repair pathway is initiated by the multifunctional enzyme
PARP-1, which recognizes the broken DNA ends by its two zinc-finger domains, Zn1 and …

Ionizing radiation (IR) is an important cancer treatment approach. However, radioresistance
eventually occurs, resulting in poor outcomes in patients with cancer. Radioresistance is …