Escherichia coli as a host for metabolic engineering
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
[HTML][HTML] From cascaded catalytic nucleic acids to enzyme–DNA nanostructures: controlling reactivity, sensing, logic operations, and assembly of complex structures
DNA is one of the most fascinating biopolymers. Besides its central role as carrier of genetic
information and translation of the genetic code into proteins, DNA holds great promise as a …
information and translation of the genetic code into proteins, DNA holds great promise as a …
Complex cellular logic computation using ribocomputing devices
Synthetic biology aims to develop engineering-driven approaches to the programming of
cellular functions that could yield transformative technologies. Synthetic gene circuits that …
cellular functions that could yield transformative technologies. Synthetic gene circuits that …
Toehold switches: de-novo-designed regulators of gene expression
Efforts to construct synthetic networks in living cells have been hindered by the limited
number of regulatory components that provide wide dynamic range and low crosstalk. Here …
number of regulatory components that provide wide dynamic range and low crosstalk. Here …
Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites
A Espah Borujeni, AS Channarasappa… - Nucleic acids …, 2014 - academic.oup.com
The ribosome's interactions with mRNA govern its translation rate and the effects of post-
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
[图书][B] The emergence of life: from chemical origins to synthetic biology
PL Luisi - 2016 - books.google.com
Addressing the emergence of life from a systems biology perspective, this new edition has
undergone extensive revision, reflecting changes in scientific understanding and evolution …
undergone extensive revision, reflecting changes in scientific understanding and evolution …
Sequence-to-function deep learning frameworks for engineered riboregulators
While synthetic biology has revolutionized our approaches to medicine, agriculture, and
energy, the design of completely novel biological circuit components beyond naturally …
energy, the design of completely novel biological circuit components beyond naturally …
A glucose meter interface for point-of-care gene circuit-based diagnostics
E Amalfitano, M Karlikow, M Norouzi, K Jaenes… - Nature …, 2021 - nature.com
Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …
Creating small transcription activating RNAs
We expanded the mechanistic capability of small RNAs by creating an entirely synthetic
mode of regulation: small transcription activating RNAs (STARs). Using two strategies, we …
mode of regulation: small transcription activating RNAs (STARs). Using two strategies, we …
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery
Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to
control cell behavior while avoiding potentially harmful genomic integration in therapeutic …
control cell behavior while avoiding potentially harmful genomic integration in therapeutic …