Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
RCSB Protein Data Bank: Enabling biomedical research and drug discovery
DS Goodsell, C Zardecki, L Di Costanzo… - Protein …, 2020 - Wiley Online Library
Analyses of publicly available structural data reveal interesting insights into the impact of the
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Abstract AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
glutamate receptors mediate fast excitatory neurotransmission throughout the central …
[HTML][HTML] Mitochondrial channels: ion fluxes and more
I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …
molecular identification of some of the channels. An integrative approach using genetics …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
[HTML][HTML] Influence of GluN2 subunit identity on NMDA receptor function
N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …
The Concise Guide to PHARMACOLOGY 2013/14: ion channels
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states
Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory signaling in
the nervous system. Despite the profound importance of iGluRs to neurotransmission, little is …
the nervous system. Despite the profound importance of iGluRs to neurotransmission, little is …