Thioamides in medicinal chemistry and as small molecule therapeutic agents

G Huang, T Cierpicki, J Grembecka - European Journal of Medicinal …, 2024 - Elsevier
Thioamides, which are fascinating isosteres of amides, have garnered significant attention in
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …

Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …

AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …

One-pot synthesis and molecular modeling studies of new bioactive spiro-oxindoles based on uracil derivatives as SARS-CoV-2 inhibitors targeting RNA polymerase …

SA El-Kalyoubi, A Ragab, OA Abu Ali, YA Ammar… - Pharmaceuticals, 2022 - mdpi.com
The first outbreak in Wuhan, China, in December 2019 was reported about severe acute
coronaviral syndrome 2 (SARS-CoV-2). The global coronavirus disease 2019 (COVID-19) …

Synthesis, characterization, biological applications, and molecular docking studies of some transition metal complexes with azo dye ligand derived from 5-methyl …

KJ Al-Adilee, SH Jawad, HAK Kyhoiesh… - Journal of Molecular …, 2024 - Elsevier
Metal complexes for Pd (II) and Pt (IV) ions were prepared and spectral identified using a
new heterocyclic azo dye ligand 2-[2′-(3, 4-dimethyl carboxy phenyl) azo]-5-methyl …

Designing metal chelates of halogenated sulfonamide Schiff bases as potent nonplatinum anticancer drugs using spectroscopic, molecular docking and biological …

RMI Elsamra, MS Masoud, AM Ramadan - Scientific Reports, 2022 - nature.com
In this contribution, five Ni (II) complexes have been synthesized from sulfonamide-based
Schiff bases (SB1–SB5) that comprise bromo or iodo substituents in the salicylidene moiety …

Unveiling the biomedical potential of thiophene‐derived Schiff base complexes: A comprehensive study of synthesis, spectral characterization, antimicrobial efficacy …

A Bhardwaj, A Dubey, A Tufail, N Tufail… - Applied …, 2024 - Wiley Online Library
In our pursuit of designing potent bioactive compounds, we synthesized six novel tellurium
(IV) complexes through the condensation of 5‐methyl‐2‐thiophene carboxaldehyde and p …

Synthesis, characterization, biological evaluation, and molecular docking approach of nickel (II) complexes containing O, N‐donor chelation pattern of sulfonamide …

AM Ramadan, HA Bayoumi… - Applied Organometallic …, 2021 - Wiley Online Library
A series of Schiff bases (L1–L4) that possess in their structure bioactive sulfonamide group
and their nickel (II) complexes have been synthesized. Microanalytical analyses, various …

Synthesis, Physicochemical Characterization, Biological Assessment, and Molecular Docking Study of Some Metal Complexes of Alloxan and Ninhydrin as …

MS Masoud, GA Yacout, BA Abd-El-Khalek… - Journal of Inorganic and …, 2023 - Springer
A series of transition metal complexes of alloxan monohydrate (H2L1) and ninhydrin (H2L2)
have been prepared where metal ions are Fe (III), Co (II), Ni (II), Cu (II), Zr (IV), and Mo (VI) …

[HTML][HTML] Schiff base coordination compounds including thiosemicarbazide derivative and 4-benzoyl-1, 3-diphenyl-5-pyrazolone: Synthesis, structural spectral …

SM Emam, S Bondock, AAM Aldaloa - Results in Chemistry, 2023 - Elsevier
A new thiosemicarbazone ligand containing an allyl group and a 5-pyrazolone derivative
has been prepared. The reaction of this ligand (H 2 L) with chloride and nitrate salts of Co …

Heterocyclic compounds with different moieties: synthesis and evaluation of biological activities assisted with the computational study

D Kısa, E Koç, KS Baş Topcu… - Journal of Biomolecular …, 2024 - Taylor & Francis
In the present work, heterocyclic compounds containing different moieties, such as pyrazole
and thiophene, were synthesized and screened for inhibitory potency against medicinal …