Review of PINK1-Parkin-mediated mitochondrial autophagy in Alzheimer's disease

TY Zhou, RX Ma, J Li, B Zou, H Yang, RY Ma… - European Journal of …, 2023 - Elsevier
Mitochondrial autophagy plays an important role in maintaining the complexity of
mitochondrial functions and removing damaged mitochondria, of which the PINK1-Parkin …

Protein interactome of amyloid-β as a therapeutic target

VF Lazarev, EA Dutysheva, IE Kanunikov, IV Guzhova… - Pharmaceuticals, 2023 - mdpi.com
The amyloid concept of Alzheimer's disease (AD) assumes the β-amyloid peptide (Aβ) as
the main pathogenic factor, which injures neural and other brain cells, causing their …

Physiologically relevant fluorescent assay for identification of 17β‐hydroxysteroid dehydrogenase type 10 inhibitors

M Schmidt, M Vaskova, A Rotterova… - Journal of …, 2023 - Wiley Online Library
Mitochondrial enzyme 17β‐hydroxysteroid dehydrogenase type 10 (HSD10) is a potential
molecular target for treatment of mitochondrial‐related disorders such as Alzheimer's …

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

O Benek, M Vaskova, M Miskerikova, M Schmidt… - European Journal of …, 2023 - Elsevier
Abstract 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a multifunctional
mitochondrial enzyme and putative drug target for the treatment of various pathologies …

Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective

M Alrouji, HM Al‐kuraishy, AI Al‐Gareeb… - …, 2024 - Wiley Online Library
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD) and Parkinson disease
(PD) are group of diseases affecting the central nervous system (CNS) characterized by …

Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity

M Hanzlova, MS Miskerikova, A Rotterova… - ACS Medicinal …, 2023 - ACS Publications
Multifunctional mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 (17β-
HSD10) is a potential drug target for the treatment of various pathologies. The most …

Mitophagy in Alzheimer's Disease: A Bibliometric Analysis from 2007 to 2022

H Wang, X Yan, Y Zhang, P Wang… - Journal of Alzheimer's …, 2024 - content.iospress.com
Background: The investigation of mitophagy in Alzheimer's disease (AD) remains relatively
underexplored in bibliometric analysis. Objective: To delve into the progress of mitophagy …

Infantile neurodegeneration results from mutants of 17β-hydroxysteroid dehydrogenase type 10 rather than Aβ-binding alcohol dehydrogenase

XY He, C Dobkin, WT Brown, SY Yang - International Journal of …, 2023 - mdpi.com
Type 10 17β-hydroxysteroid dehydrogenase (17β-HSD10), a homo-tetrameric
multifunctional protein with 1044 residues encoded by the HSD17B10 gene, is necessary for …

C-3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10

M Hanzlova, B Slavikova, M Morozovova, K Musilek… - ACS …, 2024 - ACS Publications
17β-HSD10 is a mitochondrial enzyme that catalyzes the steroidal oxidation of a hydroxy
group to a keto group and, thus, is involved in maintaining steroid homeostasis. The …

In vitro ADME, mouse pharmacokinetics of LD14b, and bioanalysis of a novel aβ 17β-HSD10 modulator for the treatment of Alzheimer's disease

S Daria, D Kumar, N Gautam, JA Alamoudi, LF Dow… - Xenobiotica, 2024 - Taylor & Francis
LD14b is an amyloid-β (Aβ) 17β-hydroxysteroid dehydrogenase type 10 (Aβ-17β-HSD10)
protein-protein interaction modulator that shows promising in vitro and ex vivo activity to …