Abstract Discs large homolog 5 (DLG5), a key member of the membrane-associated
guanylate kinase (MAGUKs) family, is a scaffold molecule for signal transduction complexes …

Tobacco smoke contains more than 4000 detectable substances, such as polycyclic
aromatic hydrocarbons, nicotine, carbon monoxide and heavy metals, which are considered …

Identifying metabolic steps that are specifically required for the survival of cancer cells but
are dispensable in normal cells remains a challenge. Here we report a therapeutic …

Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS)
has emerged as one of the most popular techniques for label-free proteome quantification in …

Among the blood cancers, 13% mortality is caused by Multiple myeloma (MM) type of
hematological malignancy. In spite of therapeutic advances in chemotherapy treatment, still …

Radioresistance is a major problem encountered in the treatment of non-small cell lung
cancer (NSCLC). Aberrant microRNA (miRNA) expression contributes to multiple cancer …

The Tumor suppressor SMAR1 (scaffold matrix attachment region binding protein 1) has a
crucial role in maintaining genomic stability, cell cycle progression and apoptosis. Our …

Background Radioresistance remains a challenge to the successful treatment of various
tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation …

Eukaryotic cells have diverse protrusive and contractile actin filament structures, which
compete with one another for a limited pool of actin monomers. Numerous actin-binding …

Lung cancer is responsible for the most cancer-related mortality worldwide and the
mechanism of its development is poorly understood. Proteomics has become a powerful tool …