PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins

MA Fierro, A Muheljic, J Sha, J Wohlschlegel, JR Beck - Msphere, 2024 - Am Soc Microbiol
Obligate intracellular malaria parasites dramatically remodel their erythrocyte host through
effector protein export to create a niche for survival. Most exported proteins contain a …

Generation of a new DiCre expressing parasite strain for functional characterization of Plasmodium falciparum genes in blood stages

A Bansal, M Sharma, H Choudhury - Scientific Reports, 2024 - nature.com
Conditional regulation is a highly beneficial system for studying the function of essential
genes in Plasmodium falciparum and dimerizable Cre recombinase (DiCre) is a recently …

Protein disulfide isomerase PDI8 is indispensable for parasite growth and associated with secretory protein processing in Toxoplasma gondii

C Wang, P Sun, Y Jia, X Tang, X Liu, X Suo, H Peng - Mbio, 2024 - journals.asm.org
Protein disulfide isomerase, containing thioredoxin (Trx) domains, serves as a vital enzyme
responsible for oxidative protein folding (the formation, reduction, and isomerization of …

Engineering mammalian cell for cancer

M Karaca, S Şen, F Fuerkaiti, UÖŞ Şeker - degruyter.com
The accuracy of products produced by mammalian cells can be explained by the fact that
continuously stored environmental information leads to high-precision production capacity …

Towards Genetic Interrogation of Putative Amino Acid Transporters in Plasmodium Falciparum Parasites

M Maré - 2023 - search.proquest.com
Malaria is a life-threatening tropical disease that caused 619 000 malaria-associated deaths
in 2021. Although malaria is a curable disease, the causative agent, the Plasmodium …

Development of a Conditional Gene Knockout System to Investigate the Functional Importance of Regulatory Genes in Plasmodium Falciparum

C van Zyl - 2023 - search.proquest.com
Malaria cases have surged in recent years, with the World Health Organization reporting
619 000 deaths in 2021. A recently approved malaria vaccine has been recommended for …