Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

Pseudorabies virus (PRV) has evolved various immune evasion mechanisms that target
host antiviral immune responses. However, it is unclear whether and how PRV encoded …

Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; …

Conclusions These data indicate that RNF5 inhibits NASH progression by targeting HRD1 in
the ubiquitin‐mediated proteasomal pathway. Targeting the RNF5–HRD1 axis may provide …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells
by interacting with host factors following infection. To understand the virus and host …

ABSTRACT DNA damage-inducible transcript 3 (DDIT3) plays important roles in
endoplasmic reticulum (ER) stress-induced apoptosis and autophagy, but its role in innate …

As an enveloped virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
contains a membrane protein (M) that mediates viral release from cellular membranes …

African swine fever is one of the most devastating swine diseases caused by African swine
fever virus (ASFV). Although ASFV encodes more than 160 viral proteins, the implication of a …