Vaccinations, especially DNA vaccines that promote host immunity, are the most effective
interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a …

In this review, published peer-reviewed preclinical studies using prime-boost tuberculosis
(TB) vaccine regimens in animal challenge models for tuberculosis have been evaluated …

Background mRNAs are highly versatile, non-toxic molecules that are easy to produce and
store, which can allow transient protein expression in all cell types. The safety aspects of …

The anti-tuberculosis vaccine, Mycobacterium bovis BCG, has been used worldwide, but its
protective efficacy is variable against adult pulmonary tuberculosis. In this study, immune …

Background In spite of a consistent protection against tuberculosis (TB) in children,
Mycobacterium bovis Bacille Calmette-Guerin (BCG) fails to provide adequate protection …

Use of therapeutic DNA vaccines is a promising strategy against tuberculosis (TB), however,
their immunogenicity still needs to be improved. In this study, a plasmid DNA vaccine …

Even after decades searching for a new and more effective vaccine against tuberculosis, the
scientific community is still pursuing this goal due to the complexity of its causative agent …

Bacille Calmette–Guerin (BCG) vaccine has been the only licensed tuberculosis (TB)
vaccine administered to humans and, until today, more than 3 billion people have received …

Mycobacterium bovis BCG is considered an attractive live bacterial vaccine vector. In this
study, we investigated the immune response of baboons to a primary vaccination with …

ABSTRACT DNA‐based vaccine is a promising candidate for immunization and induction of
a T‐cell‐focused protective immune response against infectious pathogens such as …