The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Neuronal autophagosomes form and engulf cargos at presynaptic sites in the axon and are
then transported to the soma to recycle their cargo. Autophagic vacuoles (AVs) mature en …

Macroautophagy is a homeostatic process required to clear cellular waste. Neuronal
autophagosomes form constitutively in the distal tip of the axon and are actively transported …

Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …

Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of
all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally …

Continued mRNA translation and protein production are critical for various neuronal
functions. In addition to the precise sorting of proteins from cell soma to distant locations …

Synaptic activity mediates information storage and memory consolidation in the brain and
requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses …

RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative
diseases such as Alzheimer's disease (AD) that contributes to cognitive deficits and …

Aminoacyl‐tRNA synthetases form the protein family that controls the interpretation of the
genetic code, with tRNA aminoacylation being the key chemical step during which an amino …