The recent assembly of the adult Drosophila melanogaster central brain connectome,
containing more than 125,000 neurons and 50 million synaptic connections, provides a …

The recent discoveries of microRNAs (miRNAs) and characterization of the first few targets
of their gene products in Caenorhabditis elegans and Drosophila melanogaster have set the …

Serpins are serine protease inhibitors with a conserved structure that have been identified in
nearly all species and act as suicide substrates by binding covalently to their target …

Genomics technologies have expanded the types of question that can be addressed in
human genetics and health and in fields such as ecology. Genome-scale approaches …

Bioactive peptides (ie, neuropeptides or peptide hormones) represent the largest class of
cell-cell signaling molecules in metazoans and are potent regulators of neural and …

A trypsin‐like serine protease was purified by gel filtration and anion‐exchange
chromatography from the excretory‐secretory products of parasitic phase Steinernema …

Neuronal injury triggers robust responses from glial cells, including altered gene expression
and enhanced phagocytic activity to ensure prompt removal of damaged neurons. The …

Pigment dispersing factor (PDF) is a key signaling molecule coordinating the neuronal
network associated with the circadian rhythms in Drosophila. The precursor (proPDF) of the …

A novel filarial serine protease inhibitor (SPI) from the human parasitic nematode
Onchocerca volvulus, Ov-SPI-1, was identified through the analysis of a molting third-stage …

Maturation of bone morphogenetic proteins (BMPs) requires cleavage of their precursor
proteins by furin-type proprotein convertases. Here, we find that cleavage sites of the …