[HTML][HTML] Future medicine: from molecular pathways to the collective intelligence of the body

E Lagasse, M Levin - Trends in Molecular Medicine, 2023 - cell.com
The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Neural plasticity in sensorimotor brain–machine interfaces

MC Dadarlat, RA Canfield… - Annual review of …, 2023 - annualreviews.org
Brain–machine interfaces (BMIs) aim to treat sensorimotor neurological disorders by
creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new …

Multiscale imaging informs translational mouse modeling of neurological disease

Y Wang, JM LeDue, TH Murphy - Neuron, 2022 - cell.com
Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …

Multi-scale spatio-temporal fusion with adaptive brain topology learning for fMRI based neural decoding

Z Li, Q Li, Z Zhu, Z Hu, X Wu - IEEE Journal of Biomedical and …, 2023 - ieeexplore.ieee.org
Neural decoding aims to extract information from neurons' activities to reveal how the brain
functions. Due to the inherent spatial and temporal characteristics of brain signals, spatio …

Machine learning-based high-frequency neuronal spike reconstruction from low-frequency and low-sampling-rate recordings

N Hong, B Kim, J Lee, HK Choe, KH Jin… - Nature …, 2024 - nature.com
Recording neuronal activity using multiple electrodes has been widely used to understand
the functional mechanisms of the brain. Increasing the number of electrodes allows us to …

Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity

T O'Brien, J Stremmel, L Pio-Lopez, P McMillen… - Digital …, 2024 - pubs.rsc.org
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific
enterprise. Here we address a major unmet need: use of existing scientific literature to …

Neurobiologically realistic neural network enables cross-scale modeling of neural dynamics

YJ Chang, YI Chen, HC Yeh, SR Santacruz - Scientific Reports, 2024 - nature.com
Fundamental principles underlying computation in multi-scale brain networks illustrate how
multiple brain areas and their coordinated activity give rise to complex cognitive functions …

Multimodal subspace identification for modeling discrete-continuous spiking and field potential population activity

P Ahmadipour, OG Sani, B Pesaran… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Learning dynamical latent state models for multimodal spiking and field potential
activity can reveal their collective low-dimensional dynamics and enable better decoding of …

Calibrating Bayesian decoders of neural spiking activity

G Wei, ZT Mansouri, X Wang… - Journal of …, 2024 - Soc Neuroscience
Accurately decoding external variables from observations of neural activity is a major
challenge in systems neuroscience. Bayesian decoders, which provide probabilistic …

Multimodal, multiscale insights into hippocampal seizures enabled by transparent, graphene-based microelectrode arrays

PJ Mulcahey, Y Chen, N Driscoll, BB Murphy… - eneuro, 2022 - eneuro.org
Hippocampal seizures are a defining feature of mesial temporal lobe epilepsy (MTLE). Area
CA1 of the hippocampus is commonly implicated in the generation of seizures, which may …