New applications of lipid and polymer-based nanoparticles for nucleic acids delivery
Nucleic acids represent a promising lead for engineering the immune system. However,
naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and …
naked DNA, mRNA, siRNA, and other nucleic acids are prone to enzymatic degradation and …
[HTML][HTML] Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations
GA Croitoru, AG Niculescu, D Epistatu, DE Mihaiescu… - Applied Sciences, 2024 - mdpi.com
Using nanostructured drug delivery systems has attracted increasing interest in
immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility …
immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility …
[HTML][HTML] CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategy
Hepatitis C is an inflammatory liver disease caused by the single-stranded RNA (ssRNA)
hepatitis C virus (HCV). The genetic diversity of the virus and quasispecies produced during …
hepatitis C virus (HCV). The genetic diversity of the virus and quasispecies produced during …
RNA regulatory processes in RNA virus biology
ST Cross, D Michalski, MR Miller… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Numerous post‐transcriptional RNA processes play a major role in regulating the quantity,
quality and diversity of gene expression in the cell. These include RNA processing events …
quality and diversity of gene expression in the cell. These include RNA processing events …
Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity
The recognition of pathogen-derived ligands by pattern recognition receptors activates the
innate immune response, but the potential interaction of quorum-sensing (QS) signaling …
innate immune response, but the potential interaction of quorum-sensing (QS) signaling …
Prophylactic efficacy of orally administered Bacillus poly-γ-glutamic acid, a non-LPS TLR4 ligand, against norovirus infection in mice
Poly-gamma-glutamic acid (γ-PGA), an extracellular biopolymer produced by Bacillus sp., is
a non-canonical toll-like receptor 4 (TLR4) agonist. Here we show its antiviral efficacy …
a non-canonical toll-like receptor 4 (TLR4) agonist. Here we show its antiviral efficacy …
[HTML][HTML] Designing and evaluation of MERS-CoV siRNAs in HEK-293 cell line
Abstract Background The MERS-CoV was identified for the first time from Jeddah, Saudi
Arabia in 2012 from a hospitalized patient. This virus has now been spread to 27 countries …
Arabia in 2012 from a hospitalized patient. This virus has now been spread to 27 countries …
Antiviral efficacy of orally delivered neoagarohexaose, a nonconventional TLR4 agonist, against norovirus infection in mice
M Kim, JE Lee, H Cho, HG Jung, W Lee, HY Seo… - Biomaterials, 2020 - Elsevier
The neoagarohexaose (NA6) is an oligosaccharide that is derived from agarose, the major
component of red algae cell walls, by enzymatic hydrolysis. Here we show that NA6 is a …
component of red algae cell walls, by enzymatic hydrolysis. Here we show that NA6 is a …
Synthetic antibody binding to a preorganized RNA domain of hepatitis C virus internal ribosome entry site inhibits translation
Structured RNA elements within the internal ribosome entry site (IRES) of hepatitis C virus
(HCV) genome hijack host cell machinery for translation initiation through a cap …
(HCV) genome hijack host cell machinery for translation initiation through a cap …
[HTML][HTML] In silico prediction and experimental validation of siRNAs targeting ORF1ab of MERS-CoV in Vero cell line
Abstract The Middle East Respiratory Syndrome Coronavirus is well known to cause
respiratory syndrome and this virus was identified and isolated for the first time from Jeddah …
respiratory syndrome and this virus was identified and isolated for the first time from Jeddah …