Parkinson's disease is a chronic neurodegenerative disorder characterized by the motor
symptoms of bradykinesia, tremor, rigidity and postural instability. However, non-motor …

Neuromodulatory or even neuroprotective therapy could soon be available for Parkinson's
disease (PD), raising the question of how we should define and measure disease …

ContextPramipexole and levodopa are effective medications to treat motor symptoms of
early Parkinson disease (PD). In vitro and animal studies suggest that pramipexole may …

Thirty Parkinson's disease (PD) patients were divided into three equal groups according to
their disease duration while 10 normal healthy volunteers matched for age and sex served …

Background:[123I] β-CIT and SPECT imaging of the dopamine transporter is a sensitive
biomarker of PD onset and severity. Objective: In this study, the authors examine the change …

Abstract Background Accurate diagnosis of Parkinson disease (PD) and other degenerative
parkinsonian syndromes is important for management and prognostic purposes. Diagnosis …

Parkinson disease is an age-related neurodegenerative disease that affects approximately 1
million persons in the United States. Current therapies provide effective control of symptoms …

Objective: To compare the clinical and imaging characteristics of those PRECEPT
(Parkinson Research Examination of CEP-1347 Trial) subjects with a scan without evidence …

Neuroimaging studies have documented an age-related decline in striatal dopamine
transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further …

Pathological and neuroimaging studies have shown that in Parkinson's disease (PD) there
is a “subclinical” or “premotor” period during which dopaminergic neurons in the substantia …