New insights into the pathogenesis and nonsurgical management of Graves orbitopathy

PN Taylor, L Zhang, RWJ Lee, I Muller… - Nature Reviews …, 2020 - nature.com
Graves orbitopathy, also known as thyroid eye disease or thyroid-associated orbitopathy, is
visually disabling, cosmetically disfiguring and has a substantial negative impact on a …

Insulin-like growth factor-I receptor and thyroid-associated ophthalmopathy

TJ Smith, JA Janssen - Endocrine Reviews, 2019 - academic.oup.com
Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to
emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease …

The microbiota and autoimmunity: Their role in thyroid autoimmune diseases

HL Köhling, SF Plummer, JR Marchesi, KS Davidge… - Clinical …, 2017 - Elsevier
Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD)
has been an object of intensive research. The last decade has witnessed many studies on …

Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease

S Moshkelgosha, HL Verhasselt, G Masetti, D Covelli… - Microbiome, 2021 - Springer
Background Graves' disease (GD) is an autoimmune condition in which autoantibodies to
the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have …

A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves' orbitopathy

Y Wang, Z Chen, T Wang, H Guo, Y Liu… - Cellular & molecular …, 2021 - nature.com
Abstract Graves' orbitopathy (GO), the most severe manifestation of Graves' hyperthyroidism
(GH), is an autoimmune-mediated inflammatory disorder, and treatments often exhibit a low …

The role of the microbiota in Graves' disease and Graves' orbitopathy

J Hou, Y Tang, Y Chen, D Chen - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Graves 'disease (GD) is a clinical syndrome with an enlarged and overactive thyroid gland,
an accelerated heart rate, Graves' orbitopathy (GO), and pretibial myxedema (PTM). GO is …

HIF2A–LOX pathway promotes fibrotic tissue remodeling in thyroid-associated orbitopathy

F Hikage, S Atkins, A Kahana, TJ Smith… - Endocrinology, 2019 - academic.oup.com
Thyroid-associated orbitopathy (TAO) is a disfiguring periocular connective tissue disease
associated with autoimmune thyroid disorders. It is a potentially blinding condition, for which …

Mechanisms that underly T cell immunity in graves' orbitopathy

S Fang, Y Lu, Y Huang, H Zhou, X Fan - Frontiers in Endocrinology, 2021 - frontiersin.org
Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is the most
common ocular abnormality of Graves' disease. It is a disfiguring, invalidating, and …

Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease

G Masetti, S Moshkelgosha, HL Köhling, D Covelli… - Microbiome, 2018 - Springer
Background Variation in induced models of autoimmunity has been attributed to the housing
environment and its effect on the gut microbiota. In Graves' disease (GD), autoantibodies to …

Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease

A Gulbins, M Horstmann, A Daser, U Flögel… - Frontiers in …, 2023 - frontiersin.org
Introduction Graves' disease (GD) is an autoimmune disorder caused by autoantibodies
against the thyroid stimulating hormone receptor (TSHR) leading to overstimulation of the …