Mechanical and biological effects of ultrasound: a review of present knowledge
Ultrasound is widely used for medical diagnosis and increasingly for therapeutic purposes.
An understanding of the bio-effects of sonography is important for clinicians and scientists …
An understanding of the bio-effects of sonography is important for clinicians and scientists …
Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
M Aryal, CD Arvanitis, PM Alexander… - Advanced drug delivery …, 2014 - Elsevier
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
[HTML][HTML] Acute inflammatory response following increased blood-brain barrier permeability induced by focused ultrasound is dependent on microbubble dose
Abstract Rationale: Focused ultrasound (FUS), in conjunction with circulating microbubbles
(MBs), can be used to transiently increase the permeability of the blood-brain barrier (BBB) …
(MBs), can be used to transiently increase the permeability of the blood-brain barrier (BBB) …
Ultrasound treatment of neurological diseases—current and emerging applications
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
The size of blood–brain barrier opening induced by focused ultrasound is dictated by the acoustic pressure
H Chen, EE Konofagou - Journal of Cerebral Blood Flow & …, 2014 - journals.sagepub.com
Focused ultrasound (FUS) in combination with microbubbles (MBs) has been successfully
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
used in the delivery of various-size therapeutic agents across the blood–brain barrier (BBB) …
Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model
EJ Park, YZ Zhang, N Vykhodtseva… - Journal of Controlled …, 2012 - Elsevier
Trastuzumab has shown positive results in many patients with metastatic HER2-positive
breast cancer, but it is less effective for controlling metastases in the CNS, which remains a …
breast cancer, but it is less effective for controlling metastases in the CNS, which remains a …
In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice
The in vivo cavitation response associated with blood–brain barrier (BBB) opening as
induced by transcranial focused ultrasound (FUS) in conjunction with microbubbles was …
induced by transcranial focused ultrasound (FUS) in conjunction with microbubbles was …
Translation of focused ultrasound for blood-brain barrier opening in glioma
Survival outcomes for patients with glioblastoma multiforme (GBM) have remained poor for
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
the past 15 years, reflecting a clear challenge in the development of more effective treatment …
Ultrasound-induced blood-brain barrier opening
Over 4 million US men and women suffer from Alzheimer's disease; 1 million from
Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic …
Parkinson's disease; 350,000 from multiple sclerosis (MS); and 20,000 from amyotrophic …