Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC),
ranks the fourth leading cause of cancer-related deaths in the western world. While the …

Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed
almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …

The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …

Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is
the fourth leading cause of cancer-related deaths in the world. Due to the broad …

Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …