The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain
from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria …

Highlights•Bacterial pathogens rewire host proteomes to enable their replication and
spread.•Identifying host-pathogen protein interactions elucidates pathogenic …

ABSTRACT The Chinese horseshoe bat (Rhinolophus sinicus), reservoir host of severe
acute respiratory syndrome coronavirus (SARS-CoV), carries many bat SARS-related CoVs …

Pathogenic bacteria have evolved a variety of highly selective adhesins allowing these
microbes to engage specific surface determinants of their eukaryotic host cells. Receptor …

Staphylococcal protein A (SpA) is a multifunctional, highly conserved virulence factor of
Staphylococcus aureus. By binding the Fc portion of all human IgG subclasses apart from …

Infections of the central nervous system (CNS) are still a major cause of morbidity and
mortality worldwide. Traversal of the barriers protecting the brain by pathogens is a …

Secreted proteins and their cognate plasma membrane receptors regulate human
physiology by transducing signals from the extracellular environment into cells resulting in …

Neisseria adhesin A (NadA), one of the surface adhesins of Neisseria meningitides (NM),
interacts with several cell types including human brain microvascular endothelial cells …

Neisserial adhesin A (NadA) is a meningococcal surface protein included as recombinant
antigen in 4CMenB, a protein-based vaccine able to induce protective immune responses …

Background: Host-parasite protein interactions (HPPI) are those interactions occurring
between a parasite and its host. Host-parasite protein interaction enhances the …