The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Abstract Indoleamine 2, 3 dioxygenase 1 (IDO1) is an attractive target for cancer
immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in …

A coordinated balance between the positive and negative regulation of pattern-recognition
receptor (PRR)-initiated innate inflammatory responses is required to ensure the most …

Although radiotherapy can promote antitumour immunity, the mechanisms underlying this
phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

The innate immune system utilizes pattern-recognition receptors (PRRs) to detect the
invasion of pathogens and initiate host antimicrobial responses such as the production of …

Cancer immunotherapy attempts to harness the power and specificity of the immune system
to treat tumours. The molecular identification of human cancer-specific antigens has allowed …

Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it
is only in the past five years that the molecular basis of DNA sensing by the innate immune …

Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated
and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box …