Pillars of biology: Boolean modeling of gene-regulatory networks
J Thakar - Journal of Theoretical Biology, 2023 - Elsevier
Boolean modeling is a mathematical modeling framework used for defining and studying
gene-regulatory networks (GRNs). It provides a means to develop mechanistic models …
gene-regulatory networks (GRNs). It provides a means to develop mechanistic models …
Challenges and opportunities for digital twins in precision medicine: a complex systems perspective
M De Domenico, L Allegri, G Caldarelli… - arXiv preprint arXiv …, 2024 - arxiv.org
The adoption of digital twins (DTs) in precision medicine is increasingly viable, propelled by
extensive data collection and advancements in artificial intelligence (AI), alongside …
extensive data collection and advancements in artificial intelligence (AI), alongside …
Trap spaces of multi-valued networks: definition, computation, and applications
Motivation Boolean networks are simple but efficient mathematical formalism for modelling
complex biological systems. However, having only two levels of activation is sometimes not …
complex biological systems. However, having only two levels of activation is sometimes not …
Repository of logically consistent real-world Boolean network models
Recent developments in both computational analysis and data-driven synthesis enable a
new era of automated reasoning with logical models (Boolean networks in particular) in …
new era of automated reasoning with logical models (Boolean networks in particular) in …
[HTML][HTML] Unlocking mitochondrial dysfunction-associated senescence (MiDAS) with NAD+–A Boolean model of mitochondrial dynamics and cell cycle control
The steady accumulation of senescent cells with aging creates tissue environments that aid
cancer evolution. Aging cell states are highly heterogeneous.'Deep senescent'cells rely on …
cancer evolution. Aging cell states are highly heterogeneous.'Deep senescent'cells rely on …
Boolean Networks as Predictive Models of Emergent Biological Behaviors
Interacting biological systems at all organizational levels display emergent behavior.
Modeling these systems is made challenging by the number and variety of biological …
Modeling these systems is made challenging by the number and variety of biological …
[图书][B] Boolean Networks as Predictive Models of Emergent Biological Behaviors
Interacting biological systems at all organizational levels display emergent behavior.
Modeling these systems is made challenging by the number and variety of biological …
Modeling these systems is made challenging by the number and variety of biological …
Phenotype Control of Partially Specified Boolean Networks
Abstract Partially specified Boolean networks (PSBNs) represent a promising framework for
the qualitative modelling of biological systems in which the logic of interactions is not …
the qualitative modelling of biological systems in which the logic of interactions is not …
Controllability of generalized asynchronous Boolean networks with periodical impulsive control
X Su, H Zhang, C Luo, L Xu, S Alghamdi - Communications in Nonlinear …, 2024 - Elsevier
The objective of this paper is to investigate the controllability of generalized asynchronous
Boolean networks under periodical impulsive control. In order to attain the objective, the …
Boolean networks under periodical impulsive control. In order to attain the objective, the …
From years to hours: accelerating model refinement
Network-based dynamic modeling is useful for studying how complex biomolecular systems
respond to environmental changes and internal perturbations. The main challenge in …
respond to environmental changes and internal perturbations. The main challenge in …