Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening …
RA Kardile, AP Sarkate, DK Lokwani, SV Tiwari… - European Journal of …, 2023 - Elsevier
Here in, we report the design, synthesis and in vitro anticancer activity of a novel series of 24
quinoline analogues of substituted amide and sulphonamide derivatives. The anticancer …
quinoline analogues of substituted amide and sulphonamide derivatives. The anticancer …
Bicyclic 6+ 6 systems: the chemistry of pyrimido [4, 5-d] pyrimidines and pyrimido [5, 4-d] pyrimidines
The present study provides an overview of the chemistry and biological significance of
pyrimido [4, 5-d] pyrimidine and pyrimido [5, 4-d] pyrimidine analogs as types of bicyclic [6+ …
pyrimido [4, 5-d] pyrimidine and pyrimido [5, 4-d] pyrimidine analogs as types of bicyclic [6+ …
Recent developments towards the synthesis of pyrimidopyrimidine and purine derivatives
P Debnath - ChemistrySelect, 2023 - Wiley Online Library
Fused pyrimidines scaffolds such as pyrimidopyrimidines, purines and xanthines are
important structural motifs found in various natural products and drug molecules. They are …
important structural motifs found in various natural products and drug molecules. They are …
Efficient rapid access to Biginelli for the multicomponent synthesis of 1, 2, 3, 4-tetrahydropyrimidines in room-temperature diisopropyl ethyl ammonium acetate
The diisopropyl ethyl ammonium acetate (DIPEAc)-promoted Biginelli protocol has been
developed for the first time by a successive one-pot three-component reaction of aldehydes …
developed for the first time by a successive one-pot three-component reaction of aldehydes …
Computational and Synthetic approach with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S triple mutant EGFR …
KS Karnik, AP Sarkate, SV Tiwari, R Azad… - Bioorganic …, 2021 - Elsevier
New substituted quinoline derivatives were designed and synthesized via a five-step
modified Suzuki coupling reaction. A comparative molecular docking study was carried out …
modified Suzuki coupling reaction. A comparative molecular docking study was carried out …
Design, synthesis, in silico ADME, DFT, molecular dynamics simulation, anti-tyrosinase, and antioxidant activity of some of the 3-hydroxypyridin-4-one hybrids in …
R Fazel, B Hassani, F Zare, H Jokar Darzi… - Journal of …, 2024 - Taylor & Francis
Tyrosinase is the rate-limiting enzyme in synthesizing melanin. Melanin is responsible for
changing the color of fruits and vegetables and protecting against skin photo …
changing the color of fruits and vegetables and protecting against skin photo …
Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR …
KS Karnik, AP Sarkate, SV Tiwari, R Azad… - Bioorganic Chemistry, 2021 - Elsevier
Two different schemes of novel substituted quinoline derivatives were designed and
synthesized via simple reaction steps and conditions. A comparative molecular docking …
synthesized via simple reaction steps and conditions. A comparative molecular docking …
Design and synthesis of novel conformationally constrained 7, 12-dihydrodibenzo [b, h][1, 6] naphthyridine and 7H-Chromeno [3, 2-c] quinoline derivatives as …
RA Kardile, AP Sarkate, AS Borude, RS Mane… - Bioorganic …, 2021 - Elsevier
Novel non-camptothecin (non-CPT) class of conformationally constrained, hitherto unknown
7, 12-dihydrodibenzo [b, h][1, 6] naphthyridine and 7H-Chromeno [3, 2-c] quinoline …
7, 12-dihydrodibenzo [b, h][1, 6] naphthyridine and 7H-Chromeno [3, 2-c] quinoline …
Explorations of novel pyridine-pyrimidine hybrid phosphonate derivatives as aurora kinase inhibitors
SV Tiwari, AP Sarkate, DK Lokwani, DN Pansare… - Bioorganic & medicinal …, 2022 - Elsevier
For developing novel therapeutic agents with good anticancer activities, a series of novel
pyridine-pyrimidine hybrid phosphonate derivatives 4 (a–q) were synthesized by the …
pyridine-pyrimidine hybrid phosphonate derivatives 4 (a–q) were synthesized by the …
Elucidating bis-pyrimidines as new and efficient mushroom tyrosinase inhibitors: synthesis, SAR, kinetics and computational studies
In this study, a series of novel bis-pyrimidine derivatives (1P–8P) were designed,
synthesized, characterized, and investigated for their in vitro inhibitory activity against …
synthesized, characterized, and investigated for their in vitro inhibitory activity against …