Revisiting the shikimate pathway and highlighting their enzyme inhibitors
AM Almeida, R Marchiosi, J Abrahão… - Phytochemistry …, 2024 - Springer
Absent in animals and with only seven enzymatic reactions toward the synthesis of
chorismate and aromatic amino acids, the shikimate pathway is a crucial target for …
chorismate and aromatic amino acids, the shikimate pathway is a crucial target for …
Drug Discovery for Mycobacterium tuberculosis Using Structure-Based Computer-Aided Drug Design Approach
MA Ejalonibu, SA Ogundare, AA Elrashedy… - International Journal of …, 2021 - mdpi.com
Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …
An evolutionary conservation and druggability analysis of enzymes belonging to the bacterial shikimate pathway
R Frlan - Antibiotics, 2022 - mdpi.com
Enzymes belonging to the shikimate pathway have long been considered promising targets
for antibacterial drugs because they have no counterpart in mammals and are essential for …
for antibacterial drugs because they have no counterpart in mammals and are essential for …
[HTML][HTML] Structure-based in silico approaches for drug discovery against Mycobacterium tuberculosis
ADH Kingdon, LJ Alderwick - Computational and Structural Biotechnology …, 2021 - Elsevier
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …
million death in 2019, alongside 10 million new infections. Drug resistance is a growing …
Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis
Background: The prevalence of drug-resistant organisms has steadily increased over the
past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co …
past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co …
[HTML][HTML] An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway. Antibiotics 2022, 11, 675
R Frlan - 2022 - ncbi.nlm.nih.gov
Enzymes belonging to the shikimate pathway have long been considered promising targets
for antibacterial drugs because they have no counterpart in mammals and are essential for …
for antibacterial drugs because they have no counterpart in mammals and are essential for …